Congenital Hypothyreosis (CHG)

Disease

Hypothyroidism stands for all different kind of thyroid gland hypo-function, independent of the origin. In Spanish Water Dogs sub-function of the thyroid gland can originate from a genetic source. In affected pups a delay in growth occurs, which becomes obvious at the time when normal pups from the same litter experience a growth spurt at about two weeks of age. Some pups suddenly die at this time. Opening of the eyes and the ear channels is substantially delayed and the thyroid glands (goiter) enlarge as paired swellings on the underside of the neck. Bones do not lengthen appropriately causing irreversible dwarfism.
Early diagnosis opens the possibility to circumvent most of the symptoms by a daily medication with thyroid hormones for the rest of the dogs life. Otherwise, affected dogs have a very short lifespan and normally die as puppies. The causative mutation has been found by John C. Fyfe and his group at Michigan State University.

Breed

Fox Terrier, French Bulldog, Rat Terrier, Spanish Water Dog, Tenterfield Terrier

Trait of inheritance

autosomal-recessive

Test duration

1-2 weeks after arrival of the sample in the lab

Material

The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.

Testing procedure

Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.

Questiones?

Please contact our molecular biology team for further questions.

LABOKLIN GmbH und Co.KG
Steubenstraße 4
D-97688 Bad Kissingen

Tel. 0971 /72020 oder Fax: 0971 / 7202995
Email: labogen""laboklin.de

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