Degenerative myelopathy (DM)

Disease

Canine degenerative myelopathy (DM) is a fatal, slowly progressing neuro degenerative disease with a late onset (age 8 years or older). The initial clinical sign is characterised by spastic and general proprioceptive ataxia of the hind limbs. As the disease progresses, the frequently observed asymmetric weakness ascends to affect the thoracic limbs, resulting in paraplegia. Hyporeflexia of the myotatic and withdrawal reflexes occur.
Initially, DM has been recognised as a spontaneously occurring, adult-onset spinal cord disorder in German Shepherds. Nowadays, DM has been diagnosed in several other dog breeds, including Pembroke Welsh Corgi, Boxer, Rhodesian Ridgeback and Chesapeake Bay Retriever. A mutation in exon 2 of SOD1 gene was identified as major risk factor for developing DM in many breeds so far. In the Bernese Mountain Dog breed, an additional mutation in exon 1 of SOD1 gene was characterized as being also a risk factor for DM. We offer genetic testing for both mutations in Bernese Mountain Dogs as combi or single tests.

Breed

All breeds (exon 2)

Bernese Mountain Dog (exon 1+2)

Trait of inheritance

autosomal-recessive with variable penetrance;
The mutation in the SOD1-gene which represents a major risk factor for the development of the disease is identified in the genetic test.

Test duration

3-5 days after arrival of the sample in the lab

Material

The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.

Testing procedure

Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.

Questiones?

Please contact our molecular biology team for further questions.

LABOKLIN GmbH und Co.KG
Steubenstraße 4
D-97688 Bad Kissingen

Tel. 0971 /72020 oder Fax: 0971 / 7202995
Email: labogen""laboklin.de

Links

 back to genetic diseases

 back to list for breeds


*) Partnerlaboratory

Suche:
AGB |  Impressum |  Site Map
©2018 by webDa Medien GmbH